A New Prognostic Nomogram for Extranodal NK/T cell lymphoma Based on Clinical and Pathological Parameters

Abstract

Objects: To establish a risk hierarchical model to evaluating the prognostic of ENKTCL based on the clinical and pathological parameters. Methods: 1.Based on the prognostic analysis of IHC and QDB results, the prognostic model was established (NK/T cell lymphoma International prognostic Index，NIPI). 2. The data was analyzed by R.4.1.0 and the threshold was determined. AUC was used to compare with other prognostic risk models of extranodal NK/T cell lymphoma. Results: 1. NIPI based on age, MTP53, Ki67, LDH, hemoglobin and lymphocyte/platelet ratio was divided all patients into four groups with different prognostic risk. There was significant difference among different groups by NIPI(IHC) (P<0.001)and the AUC was 0.72. There was no significant difference in prognosis by Ann Arbor stage. There were significant differences in prognosis among different prognostic model groups（P_IPI=0.00036、P_PINK＝0.00017、P_NRI＜0.001）. There was significant difference among the four groups by NIPI(QDB) (P＝0.00014) and the AUC was 0.800. Conclusion: 1. NIPI can predict the prognostic risk of ENKTCL patients and can help to achieve individual accurate diagnosis and treatment. 2. QDB analysis has more prominent advantages in accurate diagnosis and treatment, and it is expected to become an important experimental technique for clinical laboratory detection.