Prognostic Risk Factor for Early Outcomes of Patients with Myelomeningocele: A Prospective Study

Author:

Alavi Seyed Ahmad Naseri1,Rezkhah Amir2,Majdi Alireza3,Habibi Mohammad Amin4,Bagheri Mohammad Mehdi2,Jafarzadeh Fateme2,Kobets Andrew J.1

Affiliation:

1. Montefiore Medical Center and the Albert Einstein College of Medicine

2. Urmia University of Medical Sciences

3. KU Leuven

4. Tehran University of Medical Sciences

Abstract

Abstract

Introduction: Myelomeningocele (MMC) is a prevalent form of neural tube defect. Despite advancements in treatment, MMC still poses significant health risks, including complications leading to chronic disability and mortality. Identifying prognostic risk factors for early outcomes is crucial for tailored intervention strategies. Methods This prospective study involved newborns and infants diagnosed with MMC who underwent surgery between 2020 and 2023 at Urmia University of Medical Sciences. Demographic data and surgical outcomes were collected, and participants were followed up for six months. Statistical analyses were conducted using descriptive statistics, Chi-Square, and independent t-test. Results The study included 29 MMC cases, with an incidence rate of 1.4 per 10,000 live births. Lesions were predominantly located in the lumbar spine. Although mortality rates appeared to increase with ascending lesion sites, this trend was not statistically significant. Short-term outcomes revealed high morbidity and mortality rates, with neurological deficits being the most prevalent complication. Multivariable analysis identified head circumference as a significant predictor of adverse outcomes (IRR = 1.37, 95% CI = 1.02 to 1.86, p = 0.04). Furthermore, an increase in birth weight was associated with a reduction in the incidence of requiring a ventriculoperitoneal shunt (IRR = 0.99, 95% CI = 0.998 to 0.999, p = 0.02) Conclusion This prospective study highlights prognostic risk factors for early outcomes in MMC patients, emphasizing the need for personalized intervention strategies. By addressing modifiable risk factors and implementing targeted interventions, healthcare providers can strive to improve outcomes and enhance the quality of life for MMC patients.

Publisher

Research Square Platform LLC

Reference14 articles.

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4. The changing incidence of myelomeningocele and its impact on pediatric neurosurgery: a review from the Children's Memorial Hospital;Bowman RM;Childs Nerv Syst,2009

5. Spina bifida outcome: a 25-year prospective;Bowman RM;Pediatr Neurosurg,2001

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