Abstract
Background
Papillary renal cell carcinomas (pRCCs) and chromophobe renal cell carcinomas (chRCCs) are the two most prevalent subtypes of non-clear cell renal cell carcinomas (nccRCCs). As most current studies comparing partial nephrectomy (PN) and radical nephrectomy (RN) predominantly concentrate on clear cell renal cell carcinomas (ccRCCs), it is imperative to conduct an independent analysis of nccRCCs to avoid potential effects from a substantial number of ccRCC samples. This study was designed to compare the oncological outcomes of PN and RN when treating pRCC and chRCC subgroups.
Methods
A total of 320 patients from three urological surgery centers who met the criteria were enrolled in the study. Overlap weighting (OW) was used to balance confounding factors between groups. The Kaplan–Meier analysis and multivariate Cox regression model were used to assess the prognosis.
Results
In the overall cohort, after OW adjustment, the 5-year recurrence-free survival (RFS), 5-year metastasis-free survival (MFS), and 5-year overall survival (OS) for patients who underwent RN and PN were 97.1% and 97.8%, 91.6% and 89.6%, 93.7% and 91.6%, respectively. Multivariable Cox regression analysis indicated there was no significant difference in RFS, MFS, and OS between RN and PN, same results were also noted in both the pRCC and chRCC cohorts.
Conclusions
Our results indicated that PN resulted in oncological outcomes equivalent to RN in cT1-pRCC and chRCC patients. If PN is challenging, opting for RN does not compromise patient OS, RFS, and MFS.