Abstract
Background
Some studies have shown that in certain populations, obstructive sleep apnea syndrome is associated with dyslipidemia. To further clarify, it is necessary to conduct research using a large sample of the general population. This study aims to explore this association using the National Health and Nutrition Examination Survey (NHANES) database
Methods
Data sets from the NHANES database for the years 2005 to 2008 and 2015 to 2018 were used, representing American adults aged 18 and above after weighting. Information regarding OSA, lipid levels, and confounding factors was included. The relationship between OSA and abnormal lipid levels was analyzed using a generalized linear model logistic regression, and the stability of the results was explored using hierarchical analysis and other methods.
Results
The study participants' ages ranged from 18 to 90 years old. The average age of the participants was 46.75 years. In the total sample, 50.76% were male. Furthermore, the TyG exhibited diagnostic capability for OSA, with an AUC of 0.701. In the fully adjusted model, participants in the fourth quartile of the TyG index had a higher likelihood of having OSA compared to those in the first quartile [OR: 1.45; 95% CI (1.02, 2.06); P < 0.05]. Subgroup analysis revealed that being male (OR: 2.09; 95% CI (1.76, 2.45); P < 0.05), in the younger age group (OR: 2.83; 95% CI (2.02, 3.96); P < 0.05), Caucasian (OR: 2.29; 95% CI (1.93, 2.73); P < 0.05), and obese (OR: 1.54; 95% CI (1.28, 1.85); P < 0.05) were associated with a higher risk of OSA.
Conclusions
In this study, a high TyG index is closely associated with the OSA. Simultaneously, the TyG index may be an independent predictor of OSA.