Evaluation of Anti-Inflammatory Activity of Hydrogel Containing New Hybrid Nano catalyst of Ibuprofen-Loaded on Chitosan Nanoparticles for Full Thickness Burn Repair

Author:

Hashemi Seyedeh-Sara1,Mohammadi Ali-Akbar1,Tafti Ali-Mohammad Fallah1,Rad Marzieh Karami1,Rad Mohammad Navid Soltani2

Affiliation:

1. Shiraz University of Medical Sciences

2. Shiraz University of Technology

Abstract

Abstract

Objective Tissue engineering represents a promising approach for restoring or improving the functionality of damaged or missing tissues. This study investigates the fabrication and characterization of a novel hydrogel scaffold incorporating chitosan nanoparticles and New Hybrid Nano catalyst of Ibuprofen for wound healing applications. Methods The hydrogel was synthesized using a solution casting method and cross-linked with calcium chloride. A new hybrid nano catalyst derivative of ibuprofen exhibiting superior analgesic effects compared to ibuprofen was synthesized and incorporated into the hydrogel. Extensive characterization using FTIR, XRD, SEM, mechanical testing, swelling studies, degradation analysis, and cell viability assays was performed to evaluate the structural, physical, and biological properties of the scaffolds. In addition to, hydrogels containing new hybrid nano catalyst derivative of ibuprofen (compound "a") assessed as wound dressing for full-thickness wound. Results In vitro results demonstrated that the 3% chitosan nanoparticle-loaded hydrogel possessed optimal physico-chemical characteristics, porosity, biocompatibility, and supported human fibroblast cell proliferation. In vivo studies using a full-thickness wound model in rats revealed accelerated wound closure, reduced inflammation, and enhanced angiogenesis for wounds treated with the ibuprofen derivative-loaded hydrogel compared to controls. Discussion Overall, this novel alginate/collagen/chitosan nanoparticle hydrogel incorporating an ibuprofen prodrug represents a promising biomaterial for facilitating wound healing through its analgesic, anti-inflammatory, and pro-angiogenic effects. This represents a pioneering effort in developing ibuprofen-supplemented scaffolds for enhanced wound healing.

Publisher

Springer Science and Business Media LLC

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