Design of anthracyclines with extremely high cytotoxic properties-Reference-Cited by-同舟云学术

Design of anthracyclines with extremely high cytotoxic properties

Published:2024-02-14 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Moiseeva Aleksandra A.¹,Artyushin Oleg I.¹,Anikina Lada V.²,Globa Anastasiya A.²,Klemenkova Zinaida S.¹,Andreev Maxim V.¹,Radchenko Eugene V.³,Palyulin Vladimir A.³,Brel Valery K.¹

Affiliation:

1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, bld. 1, Moscow, 119991, Russia

2. Institute of Physiologically Active Compounds of the FSBIS of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the RAS

3. Lomonosov Moscow State University

Abstract

Abstract Chemotherapy with anthracycline antibiotics is a common treatment of tumours of various etiologies. Creation of highly effective cytostatics based on daunorubicin is possible by applying the method of reductive amination using polyalkoxybenzaldehydes. The obtained derivatives of anthracycline structure are up to 500 times more potent compared with daunorubicin due to the increased affinity to DNA, which is confirmed by the data of extensive biological assays and the results of molecular modeling.

Publisher

Research Square Platform LLC

Reference60 articles.

1. Martins-Teixeira, M. B.; Carvalho, I. Antitumor Anthracyclines: Progress and Perspectives. ChemMedChem 2020, 15, 933–948. DOI: 10.1002/cmdc.202000131

2. Evaluating sixty years of UK trials research in acute myeloid leukemia: lessons for trial design, past, present and future;Hills RK;Brit. J. Haematol,2020

3. Schirone, L.; Toldo, S.; Cianflone, E.; Sala, V.; Greco, E. The Role of Anthracyclines in Cardio-Oncology: Oxidative Stress, Inflammation, and Autophagy. Oxid. Med. Cell. Longev. 2022, 2022, 9862524. DOI: 10.1155/2022/9862524

4. Upcycling the anthracyclines: New mechanisms of action, toxicology, and pharmacology;Bayles CE;Toxicol. Appl. Pharmacol,2023

5. Lima, M. A. C.; Brito, H. R. d. A.; Mitidieri, G. G.; d.Souza, E. P.; Sobral, A. C. G.; Melo, H. H. M. A.; Vasconcelos, G. B.; Almeida, B. B. D. d.; Figueiredo, T. d. A. D.; Filho, M. A. A. S.; et al. Cardiotoxicity in cancer patients treated with chemotherapy: A systematic review. Int. J. Health Sci. 2022 16, 39–46. DOI: none; PMCID: PMC9682875; PMID: 36475028