The adenosine deaminase family acting on RNA 1 can be a useful diagnostic biomarker in chorioamnionitis

Abstract

Abstract Chorioamnionitis (CAM) is an acute infection leading to preterm birth. However, diagnosis of CAM before delivery is challenging because of its complicated diagnostic criteria. On the other hand, RNA editing is a phenomenon that changes the phenotype by replacing bases at the RNA level and is triggered by inflammation. We investigated the correlation between RNA editing enzyme Adenosine deaminase family acting on RNA 1 (ADAR1) and CAM in clinical specimens derived fromnon-CAM, CAM (pathologically diagnosed), and clinical CAM (clinically diagnosed) patients. ADAR1 was upregulated in the placenta of CAM and clinical CAM patients (p<0.001 and p=0.005). ADAR1 had a significantly higher area under the curve (AUC) (0.735 and 0.828) than other genetic characteristics in diagnosing CAM and clinical CAM patients. ADAR1 also had significantly higher AUC (0.701 and 0.837) than other clinical characteristics for CAM and clinical CAM patients. ADAR1 can be a useful diagnostic biomarker in CAM patients before delivery.