Combination of Lymphocyte Count and Albumin Concentration as a New Prognostic Biomarker for Colorectal Cancer

Abstract

Abstract Purpose: In this study, it is aimed to evaluate the prognostic importance of lymphocytexalbumin (LA) combination in patients having colorectal cancer who underwent curative resection, besides its relationship with postoperative complications. Method: Patients who underwent curative surgery for colorectal cancer between the dates of January 2015 and January 2019 were included in the study. We defined the LA as lymphocyte count (/L)×albumin (g/L). The cut-off point was determined by ROC curves. The patients were divided into two groups according to the cut-off point: Group 1 (Low LA) and Group 2 (High LA). Demographic, clinical and pathological characteristics and survival times were compared between the two groups. Results:Patients are divided into two groups based on the cut off point of 4413 Groups were comparable with respect to age, gender, ASA score, The rate of rectal tumor location was higher in Group 1 (60% vs 32.9 p<0.001). Rates of postoperative complications, unplanned readmission, and reoperation were similar in the groups. Low LA was found to be an independent risk factor with regards to decreased survival in multivariate analysis. (HR(95%-Cl) 2.840(1.332-6.057)p:0.007). Overall and disease free survival rates were lower in Group 1 compared to Group 2 (44.2 vs 51.02 p:0.005; 47.1 vs 52.18 p:0.025, respectively). Conclusion: This study indicated decreased overall and DFS associated with low LA index in patients managed with curative treatment for colorectal cancer. No association was found between LA index and postoperative quality markers. LA might be a new prognostic biomarker for colorectal carcinoma.