Effect of non-surgical periodontal therapy on salivary and serum bone turnover markers in periodontitis

Abstract

Abstract Objective: Determining whether non-surgical periodontal therapy (NSPT) will affect bone turnover biomarkers (BTMs) concentration in individuals with periodontitis. Materials and Methods: 60 females aged 18-45 years were divided into two groups Normal (N) (n= 20) and Chronic periodontitis (CP) (n= 40) after recruitment. Participants with periodontitis were assigned (NSPT). Full mouth clinical periodontal parameters, salivary and serum BTMs including C-terminal telopeptides of type I collagen (CTX), bone alkaline phosphatase (BALP), and Osteoprotegerin (OPG) were recorded for both groups and 21 days and 3 months after NSPT. Results: Except for BALP_ SER (p<0.023), all variables had highly significant differences (p<0.001). Except for CP (21 days) vs. CP (3 months), groups showed significantly greater levels of PI, PPD and CAL. Correlations between BTMs and periodontal measurements were weak to moderate after NSPT. The multiple linear regression model explained 46.7% of the total variability for PI, 50.1% for PPD, 54.1% for CAL and 29.3% for GI signifying association with BTMs among groups Conclusion: Our research showed the concentration of BTMs is greatly impacted by NSPT demonstrating the significance of NSPT on bone health in periodontitis. Additionally, we discovered that serum instead of salivary samples can be utilized as a diagnostic tool to measure BTMs concentration. Clinical Relevance- This study emphasizes the significance of regular periodontal evaluation and the use of non-surgical periodontal therapy (NSPT) to manage periodontitis and prevent further bone loss. It also highlights the value of using serum samples as a diagnostic tool to monitor bone health in periodontitis patients.