Antioxidant and genotoxic activity of Pistacia terebinthus and Ephedra alata crude extracts

Author:

HARIR Mohammed1,Bnedif Hamdi2,Reimann hauker3,Filomena Silva4,Nerin Cristina5,Hintzsche Henning6

Affiliation:

1. Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf

2. Université de M'Sila

3. University of Würzburg

4. University of Zaragoza

5. Centro de Investigación y Tecnología Agroalimentaria de Aragón

6. University of Bonn

Abstract

Abstract

In the last decades, cases of poisoning due to medicinal plants have been very common in many countries including Algeria. Algerian herbal medicines have been used in effectively treating several health problems, but their toxicity limits their use. Pistacia terebinthus and Ephedra alata herbal medicine collected from Algeria have been used for a long time to treat several diseases. Thus, this study aimed to investigate the chemical composition and evaluate the genotoxicity and the antioxidant activity of crude extracts of these two herbal medicines (E. alata and P. terebinthus) traditionally used in Algeria and North Africa. For this purpose, genotoxicity was assessed using the micronucleus test. Additionally, compounds with antioxidant and genotoxic activities of these two plants were identified by gas chromatography coupled to mass spectrometry (GC-MS). The highest antioxidant capacity of the extracts was found in P. terebinthus ethanol extract owing to its richness of daphnetin, and oleic acid amide. Our results showed that most of these plants exhibited antioxidant activities and genotoxic effects, depending on the level of administered doses. To our knowledge, this is the first report on these effects caused by of both plants.

Publisher

Springer Science and Business Media LLC

Reference27 articles.

1. Protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis and oxidative stress in rat;Abidi A;Nutr Cancer,2017

2. Biological Effects, and Possible Molecular Mechanisms of Ephedra alata;Aidi Wannes W;Futur Integr Med,2023

3. Anticancer effect in human glioblastoma and antioxidant activity of Petroselinum crispum L. methanol extract;Aissani N;Nutr Cancer,2021

4. Analysis of phenolic and flavonoids of wild Ephedra alata plant extracts by LC/PDA and LC/MS and their antioxidant activity;Al-Rimawi F;African J Tradit Complement Altern Med,2017

5. Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)-A review;Al-Snafi AE;IOSR J Pharm,2017

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