Abstract
Background
The lipid accumulation product (LAP) is an efficient indicator for identifying individuals with various metabolic disorders. However, the association between LAP and gallstones is uncertain. In this study, we examined the association between LAP and gallstones.
Methods
The data obtained from individuals ≥ 20 years old who participated in the National Health and Nutrition Examination Survey (NHANES) between March 2017 and 2020 (pre-pandemic) were analyzed. Logistic regression, nonlinear regression, subgroup, and sensitivity analyses were conducted to determine the relationship between LAP and gallstones.
Results
Among the 2,755 participants (mean age: 50.4 ± 17 years, 48.7% female), 301 individuals (12.3%) suffered from gallstones. Each unit increase in LAP, after natural logarithm (Ln) conversion, was associated with a 59% increase in the incidence of gallstone (OR = 1.59, 95% CI: 1.24, 2.05) in the fully adjusted model, particularly in females, non-Hispanic Whites, and other races/ethnicities, and individuals without coronary heart disease (CHD) and diabetes.
Conclusions
LAP is positively associated with the incidence of gallstones.