Functional Neural Networks of Physical Reserve Moderate the Association between White Matter Hyperintensity and Postural Balance in Older Adults with Subcortical Ischemic Vascular Cognitive Impairment-Reference-Cited by-同舟云学术

Functional Neural Networks of Physical Reserve Moderate the Association between White Matter Hyperintensity and Postural Balance in Older Adults with Subcortical Ischemic Vascular Cognitive Impairment

Published:2024-05-21 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Hsu Chun Liang¹,Holtzer Roee²,Tam Roger³,Alkeridy Walid⁴,Liu-Ambrose Teresa³

Affiliation:

1. Hong Kong Polytechnic University

2. Albert Einstein College of Medicine

3. University of British Columbia

4. King Saud University

Abstract

White matter hyperintensities (WMH) are markers of subcortical ischemic vascular cognitive impairment (SIVCI) associated with impaired postural balance. Physical reserve (PR) is a recently established construct that reflects one’s capacity to maintain physical function despite brain pathology. This cross-sectional study aims to map functional networks associated with PR, and examining the relationship between PR, WMH, and postural balance. PR was defined in 22 community-dwelling older adults with SIVCI. Functional networks of PR were computed using general linear model. Subsequent analyses examined whether PR and relevant networks moderated the relationship between WMH and postural balance under two conditions – eyes open while standing on foam (EOF) or on floor (EONF). We found that PR and the relevant networks - frontoparietal network (FPN) and default mode network (DMN) - significantly moderated the association between WMH and postural balance. For individuals with high PR, postural balance remained stable regardless of the extent of WMH load; whereas for those with low PR, postural balance worsened as WMH load increased. These results suggest the attenuated effects of WMH on postural stability due to PR may be underpinned by functional neural network reorganization in the FPN and DMN as a part of compensatory processes.

Publisher

Springer Science and Business Media LLC

Reference52 articles.

1. Barber R, Scheltens P, Gholkar A, et al. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging. Research Support, Non-U.S. Gov't. Journal of neurology, neurosurgery, and psychiatry. Jul 1999;67(1):66–72.

2. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Research Support, Non-U.S. Gov't;Breteler MM;Neurology. Jul,1994

3. White matter predictors of cognitive functioning in older adults. Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't;Meier IB;Journal of the International Neuropsychological Society: JINS. May,2012

4. Silbert LC, Howieson DB, Dodge H, Kaye JA. Cognitive impairment risk: white matter hyperintensity progression matters. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't. Neurology. Jul 14 2009;73(2):120-5. doi:10.1212/WNL.0b013e3181ad53fd

5. Whitman GT, Tang Y, Lin A, Baloh RW. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Research Support, U.S. Gov't, P.H.S. Neurology. Sep 25 2001;57(6):990-4.