Is the absolute lymphocyte count a biomarker for neonates with necrotizing enterocolitis needs surgical consultation?

Author:

Zhong# Weitao1,Chen# Jiale1,He Qiuming1,He Juan1,Zou Pengjian1,Tian Yan1,Ma Zuyi1,Zhong Wei1

Affiliation:

1. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University

Abstract

Abstract Background: Previous studies reported contradicting results about the association between the absolute lymphocyte count and necrotizing enterocolitis. The aim of this study was to explore whether the absolute lymphocyte count of (ALC) can be a biomarker for neonates with necrotizing enterocolitis needs surgical consultation. Methods: We retrospectively analyzed perinatal data, clinical features before NEC onset (T0), laboratory values at T0 and at the time within the 24h after NEC onset(T1) from neonates with confirmed NEC who were admitted to Guangzhou Women and Children’s Medical Center from January 2016 to June 2021. Univariate and multivariate logistic regression analyses were used to evaluate predictive factors of surgical NEC. Receiver operating characteristics analysis was used to evaluate cutoffs and predictive values. Results: Overall, 224 neonates with NEC were identified, including 80 cases (35.7%) underwent surgical intervention (surgical NEC) and 144 cases (64.3%) were managed with conservative treatment (medical NEC). Multivariate Logistic regression analysis showed that male gender [p value, adjusted odds ratio [95%CI]; 0.002, 3.36(1.53-7.35)], low ALC on T1[(<0.001, 0.37(0.25-0.55)] were identified as independent risk factors for surgical NEC. The area under curve (AUC) of ALC on T1 was 0.814 (95% CI 0.757~0.871). The optimal cut-off value was 2.10*109/L with 80% sensitivity and 74% specificity. Conclusion: In neonates with NEC, low ALC may indicate a higher probability of needing surgical intervention. Timey surgical consultation may assist in the early diagnosis of the surgical NEC and avoid missing the optimal timing of surgery.

Publisher

Research Square Platform LLC

Reference25 articles.

1. Walker. Necrotizing enterocolitis;Neu J;N Engl J Med,2011

2. B. Surgical necrotizing enterocolitis;Robinson JR;Semin Perinatol,2017

3. Contemporary Outcomes for Infants with Necrotizing Enterocolitis-A Systematic Review;Jones IH;J Pediatr,2020

4. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis;Rees CM;Arch Dis Child Fetal Neonatal Ed,2007

5. Neonatal independent predictors of severe NEC;Duci M;Pediatr Surg Int,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3