AT1R gene polymorphism contributes to MACCEs in Hypertension patients

Abstract

Abstract OBJECTIVE: To investigate the possible association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertension patients combined with or without coronary heart disease (CHD) in Xinjiang. METHODS: 374 CHD patients and 341 non-CHD individuals were enrolled as study participants and all of them have a hypertension diagnosis. AT1R gene polymorphisms were genotyped by SNPscan™ typing assays. During the follow-up in the clinic or by telephone interview, MACCEs were recorded. Kaplan–Meier curves and Cox survival analyses were used to explore the association between AT1R gene polymorphisms and the occurrence of MACCEs. RESULTS: AT1R gene rs389566 was associated with MACCEs. The TT genotype of the AT1R gene rs389566 had a significantly higher probability of MACCEs than the AA+AT genotype (75.2% vs 24.8%, P=0.033). Older age (OR=1.028, 95% CI: 1.009-1.0047, P=0.003) and TT genotype of rs389566 (OR=1.770, 95% CI: 1.148-2.729, P=0.01) were risk factors of MACCEs. AT1R gene rs389566 TT genotype may be a predisposing factor for the occurrence of MACCEs in hypertensive patients. CONDLUSION: AT1R SNP rs389566 may be a common genetic loci and optimal genetic susceptibility marker for MACCEs in hypertension patients.