Serum 25 hydroxyvitamin D levels and stress urinary incontinence: Mendelian randomization analysis

Abstract

Abstract Background Previous observational studies have found an association between vitamin D and stress urinary incontinence(SUI), but it remains controversial and the causal relationship is unknown. In the present study, we investigated the causal relationship between vitamin D and stress urinary incontinence through a Mendelian randomization study. Methods Summary statistics for 25(OH)D and SUI were obtained from genome-wide association studies (GWAS). To explore the potential causal relationship between them, MR analysis was applied. The causal effects were mainly estimated using the standard inverse variance weighting (IVW) method. Additionally, complementary and sensitivity analyses were conducted using various methods to ensure the accuracy of the results. Results Genetically determined stress incontinence did not correlate with 25(OH)D levels (all P > 0.05, 95% CI for OR passed 1), and did not support a causal effect between 25(OH)D and stress incontinence (IVW OR: 1.002259, 95% CI: 0.9991954–1.005332, P = 0.1485497). Conclusion Our results found no causal relationship between 25(OH)D and stress urinary incontinence.; further observational studies and clinical trials are warranted.