Sex and gender correlates of sexually polymorphic cognition

Abstract

Abstract Background: Sexually polymorphic cognition (SPC) results from the interaction between biological (birth-assigned sex (BAS), sex hormones) and sociocultural (gender identity, gender roles, sexual orientation) factors. The literature remains quite mixed regarding the magnitude of the effects of these variables. This project used a battery of classic cognitive tests designed to assess the influence of sex hormones on cognitive performance. At the same time, we aimed to assess the inter-related and respective effects that BAS, sex hormones, and gender-related factors have on SPC. Methods: We recruited 222 adults who completed eight cognitive tasks that assessed a variety of cognitive domains during a 150-minute session. Subgroups were recruited as follows: cisgender heterosexual men (n = 46), cisgender non-heterosexual men (n = 36), cisgender heterosexual women (n = 36), cisgender non-heterosexual women (n = 38), gender diverse (n = 66). Saliva samples were collected before, during, and after the test to assess testosterone, estradiol, progesterone, cortisol, and dehydroepiandrosterone. Psychosocial variables were derived from self-report questionnaires. Results: Cognitive performance reflects sex and gender differences that are partially consistent with the literature. Interestingly, biological factors seem to better explain differences in male-typed cognitive tasks (e.g., spatial), while psychosocial factors seem to better explain differences in female-typed cognitive tasks (e.g., verbal). Conclusion: Our results provide a solid foundation for better understanding SPC by going beyond BAS as a binary. We highlight the importance of treating sex as a biological factor and gender as a sociocultural factor together since they collectively influence SPC.