Affiliation:
1. Hiroshima University
2. Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Abstract
Abstract
Background. Episil® is a non-absorbable liquid medical material used to cover and protect oral lesions, particularly those caused by mucositis associated with chemotherapy and radiation therapy. While there are some scattered reports on its use in head and neck cancer, there have been few studies in other malignancies.
Methods. In this study, 38 patients with hematologic malignancies treated for oral mucositis (OM) with Episil® at the Hiroshima Red Cross & Atomic-bomb Survivors Hospital were included; the degree of OM before and after use was examined. Of these 23 patients were interviewed about the effects of OM on pain, conversation, and eating, using our original evaluation protocol, and the results were compared.
Results. The severity of mucositis decreased after the use of Episil® in eight patients (21%), particularly in those with mucositis at multiple sites. Patient evaluations showed significant pain relief and improvements in speech and feeding functions. Patients with Grade 3 mucositis had higher ratings for improvement in pain relief, speech, and eating functions than those with Grade 2.
Conclusions. Episil® performed well in patients with hematologic malignancies and was particularly effective in multiple mucositis. In addition to pain relief, Episil has been suggested to improve speech and feeding functions effectively.
Publisher
Research Square Platform LLC
Reference34 articles.
1. A study of oral mucosal ulcers in leukemia patients Changes in plasma coagulation Factor XIII, plasma -fibronectin,and a2- plasmin inhibitor levels;Tamashige M;Japanese J Oral Maxillofacial Surg
2. Quinn B, Dargan S, Campbell F, Fulman L, Gemmill J, Harding J et al. United Kingdom Oral Care in Cancer Guidance: Third Edition. http://ukomic.com/guidance.htmlã2019ã.
3. Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials;Colella G;Curr Oncol,2023
4. Oral Mucositis Due to High-Dose Chemotherapy and/or Head and Neck Radiation Therapy;Lalla RV;JNCI Monogr,2019
5. A study of stomatitis during the treatment of acute myelocytic leukemia;Yoshida M;J Japanese Soc Oral Mucous Membrane,2010