Maternal Oxygen Inhalation Affects the Fetal Hemodynamic in Low-Risk with Uncomplicated Late Pregnancy

Abstract

Abstract Background Maternal oxygen inhalation is associated without significant benefit in newborn during labor. However, it is unknown whether maternal oxygen inhalation effects are fetal hemodynamic in late pregnancy. Objective We aimed to determine late trimester whether oxygen inhalation and fetal hemodynamic change are relevant, and attempt to quest the effect of short-term maternal oxygenation inhalation on fetal hemodynamic change, and appraise whether this practice could have any benefit or potential harmful in fetus. Study Design This retrospective data was obtained from singleton pregnancies who underwent a after 32+ 0 weeks prenatal ultrasound examination between January 2022 and December 2022, with and without oxygen inhalation women. Our study analysis was performed in August 2023. In oxygen inhalation group, pregnant women received oxygen inhalation with 3 liters/minute for 30 minutes by nasal cannula, and before went to department of ultrasound for sonographic assessment within 1 hour. Each woman was recorded doppler index and calculated placental pulsatility index (PPI) and cerebroplacental ratio (CPR). Moreover, fetal cardiac function was assessed within pulsed Doppler or M-mode. Main outcome The primary outcome presented higher PPI, lower CPR, and lower birth weight for the exposure maternal oxygen inhalation group, compare to non-oxygen inhalation group. Results Among 104 singleton fetuses (oxygen inhalation group: 48) between 18+ 0 and 40+ 6 weeks of gestation in the final study. In spite of resistance index values of uterine arteries, umbilical arteries, middle cerebral arteries, descending aorta, ductus venosus, and umbilical vein were not reached the statistical different, the data still had variants on oxygen inhalation group. Most importantly, the index of higher sensitivity predicting adverse outcome, PPI (0.76 ± 0.11 vs. 0.81 ± 0.12, p < 0.05) and CPR (2.28 ± 0.70 vs. 1.98 ± 0.56, p < 0.05), presented statistical difference. Meanwhile, birth weight was lower in oxygen inhalation group (2983.78 ± 468.18gm vs. 3178.41 ± 477.59gm, p < 0.05) in our study. Conclusion The change in the more sensitive index for predicting unfavorable prenatal outcome, higher PPI and lower CPR, correlated strongly with the maternal oxygen inhalation group compared with the non-oxygen inhalation group. Our results might could be assisted a careful evaluation of the decision-making process and feasibility evaluation in the treatment of oxygen inhalation in pregnancy women especially high-risk pregnancies. Concurrently provided the gauging doppler index for observation before and after treatment in the necessary situation also.