Synthesis, Crystal Structure and Antimicrobial activities of Two Silver(I) Complexes Based on Bis(pyrazole) and Carboxylic Acid Co-ligands

Abstract

Abstract Two dinuclear and centrosymmetric silver-containing complexes namely [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(tbtc)] (1) and [Ag2(3,5-dmpz)2(3,5-dmpz methanol)2(dbtc)] (3,5-dmpz: dimethypyrazole; 3,5-dmpz methanol: 3,5-dimethylpyrazole methanol; tbtc: Tetrabromoterephthalic acid; dbtc: 2,5-Dibromoterephthalic acid) were prepared and characterized. X-ray crystallographic data of 1 and 2 revealed that trigonal environment of the Ag ions have a “Compressed Y’s” geometry. The antimicrobial activity of 1 and 2 was tested against the Gram-positive, Gram-negative bacteria and fungus, displaying the better inhibiting activity than the individual AgNO3 and 3,5-dimethylpyrazole, especially for Candida albicans (IC50-2.54 mg mL− 1 and 2.79 mg mL− 1). The quantified IC50 values displayed that complexes 1 and 2 were more effective against fungus than the Gram-negative bacteria and Gram-positive bacteria.