Clinical features and prognostic factors of acute glufosinate ammonium

Abstract

Abstract This retrospective study was conducted on 67 patients who suffered from acute oral glufosinate ammonium poisoning to summarize a comprehensive overview of the clinical characteristics. General clinical data and laboratory test results were collected from the time of admission to hospital discharge. The most common clinical symptom of GA poisoning were nausea and vomiting, The incidence of unfavorable outcomes and the mortality of GA poisoning were 41.8% and 13.4%. The unfavorable outcomes group had a higher initial serum ammonia level (75.7±17.3umol/L vs 47.5±12.8umol/L), more ingestion amount of GA (103.6±63.4ml vs 72.3±37.7ml) and higher-level CK-MB (43.5 U/L vs 16.0 U/L) compared to favorable outcomes groups. The area under the curve in the ROC analysis for the predictive variables, initial ammonia and CK-MB, were 0.873 and 0.680.The patients with GA poisoning may exhibit clinical symptoms of gastrointestinal and neurological toxicity, as well as respiratory failure which experience different latent period that we need to pay special attention to. Initial serum and CK-MB might be the most accurate prognostic factors for predicting the unfavorable outcomes.