Comprehensive Analysis of the Prognostic Values and Immune Implication of ESYT3 in Lung Adenocarcinoma

Abstract

Abstract Objectives: Few studies have reported the association between ESYT3 and tumors. The purpose of this study was to investigate the molecular features and potential roles of ESYT3 in lung adenocarcinoma. Methods: GEPIA, UALCAN, KM Plotter and TCGA databases were primarily used to study ESYT3 mRNA expression profiles and prognostic values in patients with LUAD. Then we evaluated coexpressed genes of ESYT3 by cBioPortal online tools and performed enrichment analysis using Metascape. Moreover, the relationship between ESYT3 and immune infiltrating cells was explored via TIMER2. Finally, MethSurv database were used to conduct methylation analysis. Results: We found ESYT3 was down-regulated in LUAD tissues based on TCGA and GEPIA databases. Low expression of ESYT3 mRNA was observed to be significantly correlated with N classification and stage classification. GEPIA2, KM Plotter and UALCAN databases showed that low expression levels of ESYT3 was associated with poor survival in LUAD patients. The enrichment analysis indicated that co-expressed genes of ESYT3 were highly enriched in cell division. Then, our study showed ESYT3 was correlated with immune infiltration and immune checkpoints. Additionally, hypomethylation was associated with low ESYT3 expression and poor prognosis in LUAD. Conclusion: This study suggested ESYT3 could be a potential prognostic marker and a promising therapeutic target in LUAD.