PAMR1 is a favorable diagnostic and prognostic biomarker in hepatocellular carcinoma

Author:

Zhou Xiaoping1,Liu Teng1,Deng Shihua1,Zhang Ting1,Wu Dongming1,Xu Ying1

Affiliation:

1. Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College

Abstract

Abstract Peptidase domain containing associated with muscle regeneration 1 (PAMR1) is downregulated in breast cancer and cervical cancer. This study aimed to evaluate the role of PAMR1 in hepatocellular carcinoma (HCC) and explore the underlying molecular mechanisms. Base on the analysis of datasets from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA), a lower mRNA level of PAMR1 was detected in HCC compared that in normal liver tissues. The result was also confirmed by the experiment with immunohistochemistry (IHC), and qRT-PCR. The area under the curve(AUC) was 0.918 through receiver operating characteristic (ROC) curve analysis. The Kaplan-Meier analysis revealed that lower PAMR1 expression predicted prognostic outcome. Then, the genes closely associated with PAMR1 were screened and enriched by Gene Ontology (GO) analysis, showing their role on extracellular matrix organization, cell adhesion, and blood vessel development. Moreover, PAMR1 expression was positively correlated with immune cells infiltration. In addition, Gene Set Enrichment Analysis (GSEA) showed that the downregulated genes in the low-PAMR1 subgroup were significantly enriched in an inflammatory response, hypoxia, epithelial-mesenchymal transition, KRAS signaling, and TNF-α signaling via NF-κB signaling pathway. Collectively, PAMR1 shows lower level in HCC,and represents a favorable diagnostic and prognostic factor for HCC.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3