Longitudinal relationships between non-motor symptoms and biomarkers as a function of motor symptom asymmetry in early Parkinson’s disease

Author:

Voruz Philippe1ORCID,Constantin Ioana1,Peron Julie1ORCID

Affiliation:

1. University of Geneva

Abstract

Abstract Motor symptom asymmetry, a key feature of Parkinson’s disease, has been associated with differences in non-motor symptoms, such as cognitive and neuropsychiatric impairments, and in biomarker profiles. However, the longitudinal relationship between biomarkers and non-motor symptoms as a function of motor symptom asymmetry remains to be fully explored in early-stage patients. Clinical data from the Parkinson’s Progression Marker Initiative was extracted from 179 patients showing predominantly left-sided motor symptoms and 234 patients showing predominantly right-sided motor symptoms during a 3-year follow-up. General estimating equations revealed differential relationships over time between biospecimen and cognitive-neuropsychiatric scores based on motor symptom asymmetry. A more important implication of uric acid and beta-amyloid was noted in patients with predominantly left-sided motor symptoms, whereas patients with predominantly right-sided motor symptoms showed associations with alpha-synuclein and phosphorylated-tau levels. In summary, asymmetry of motor symptoms influences clinical trajectories in early-stage patients, holding important implications for symptom management in this clinical population.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3