Affiliation:
1. Shulan International Medical College, Zhejiang Shuren University
Abstract
Abstract
Transient receptor potential-canonical (TRPC) channels are non-selective cation channels, which have highly selective permeability to calcium ions. TRPC channels start to be expressed early in embryonic development and remain present until adulthood. In the brain, TRPC channels regulate the depletion of second messengers and calcium stores and are activated by a range of mechanisms. Increasing evidence suggests that TRPC channels are associated with regulating basic neural function. TRPC channels have some association with neurodevelopment, neural cell proliferation, and differentiation. In addition, TRPC channels are believed to play a relevant role in neurosecretion, LTP, and synaptic plasticity. Over the past few years, several important studies have linked TRPC channels to neurons, and constantly emphasized the decisive contribution of this group of channels in modulating neural function. In this paper, we review the role of TRPC channels in neurodevelopment, mature nervous system, and neurological diseases.
Publisher
Research Square Platform LLC
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