Post-Malaria Neurological Syndrome (PMNS): a rare case report with brain biopsy findings

Author:

Alawad Mouhammad J1,Almayoof Moustafa1,bozom Adel Al1,Alkhidir Taha1,Emam Saeed S1,Farfar Khalifa2

Affiliation:

1. Hamad Medical Corporation

2. Al Wakra hospital, Hamad Medical Corporation

Abstract

Abstract Post-malaria neurological syndrome (PMNS) is a rare, self-limiting condition that presents with a wide range of neurological manifestations after clearance of malarial infection, especially Plasmodium Falciparum, most patients recover without residual deficits. Here we present a case of a 29-year-old, male with a recent history of malaria treated successfully, who presented due to a generalized tonic-clonic seizure, without any other neurological symptoms, the examination and labs were unremarkable, he underwent a computer tomography (CT) scan and Magnetic resonant imaging (MRI) which both showed two areas of vasogenic edema involving the subcortical white matter of left frontal and right posterior parasagittal regions, all autoimmune screens, infection workup from blood and CSF were negative, he underwent a brain biopsy that showed intense perivascular inflammation with neuronal loss and gliosis, findings are nonspecific and can be seen in a variety of condition. The patient’s condition improved, and he was discharged without any complications.

Publisher

Research Square Platform LLC

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