Association Between Maternal Hypertension and Infant Neurodevelopment in Extremely Preterm Infants-Reference-Cited by-同舟云学术

Association Between Maternal Hypertension and Infant Neurodevelopment in Extremely Preterm Infants

Published:2023-09-25 Issue: Volume: Page:
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Author:

Dayan Natalie¹,Abdelmageed Wael²,Lapointe Anie³,Brown Richard⁴,Gorgos Andreea⁵,Luu Thuy Mai,Beltempo Marc⁶^ORCID,Altit Gabriel⁷^ORCID

Affiliation:

1. McGill University Health Centre

2. Division of Experimental Medicine, McGill University Health Center

3. Division of neonatology, Sainte-Justine University Hospital Center

4. Research Institute McGill University Health Centre

5. Montreal Children's Hospital, McGill University

6. Montreal Children's Hospital, McGill University Health Centre

7. Montreal Children's Hospital

Abstract

Abstract Objective: To examine the association between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) at 24 months post-menstrual age in extremely preterm infants. Study Design: Using data from two tertiary neonatal units (2011-2017) for infants born at 23+0 to 28+6 weeks, we investigated outcomes of NDI related to maternal hypertension and small-for-gestational-age (SGA) status. Results: Of 1019 pre-term infants, 647 had complete data and were included in the analysis. Ninety-six (15%) had maternal hypertension exposure; 25 (4%) were also SGA. Infants with maternal hypertension showed a higher odds of any NDI (aOR: 2.29, 95% CI=1.36-3.87) and significant NDI (aOR: 2.01, 95% CI=1.02-3.95). The combination of hypertension and SGA further elevated this risk (aOR for any NDI: 4.88, 95% CI=1.80-13.22; significant NDI: 6.91, 95% CI=2.50-19.12). Conclusion: Maternal hypertension during pregnancy elevates the risk of NDI in extremely preterm infants, more so when combined with SGA.

Publisher

Research Square Platform LLC

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