The role of systemic inflammatory response index (SIRI) and tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with laryngeal squamous cell carcinoma

Abstract

Abstract Objectives: Systemic inflammatory response index (SIRI) values and tumor-infiltrating lymphocytes (TILs) are associated with the prognosis of various tumors. There is minimal evidence of those two as prognostic markers in laryngeal squamous cell carcinoma (LSCC). In this study, we aimed to examine the predictive value of SIRI and tumor-infiltrating CD3+/CD4+/CD8+T-cells in the prognosis of patients who underwent partial or total laryngectomy. Study Design: A total of 78 patients with LSCC who underwent total or partial laryngectomy at the Eye, Ear, Nose, and Throat Hospital of Fudan University between 2013 and 2015 were retrospectively analyzed. Methods: The tumor tissues of 78 LSCC patients were retrospectively evaluated using immunohistochemical staining for CD3+/CD4+/CD8+ -cells. The overall survival (OS) and disease-free survival (DFS) rates were recorded using the Kaplan-Meier method. Results: Patients with high immunoscore (IS) (3~4) had prolonged survival (P<0.001 for OS). High SIRI values were independently associated with poorer OS and DFS (P=0.018 for OS; P=0.016 for DFS). CD8+TILs and SIRI values showed a positive association (Pearson’s r = -0.2988, P<0.05). Patients with low SIRI values and high IS had better 5-year OS and DFS than those with high SIRI values and low IS (P<0.001 for OS; P=0.0014 for DFS). Patients with ‘hot’ tumor had a higher 5-year OS than those with ‘excluded’ or ‘cold’ phenotype. Conclusions: The SIRI values and the density of TILs may help predict LSCC patients' outcomes after surgery. The combination of SIRI and IS may be a new component of the tumor, nodes, and metastases (TNM) classification of cancer and prognostic factor for T cell-target immunotherapy.