Up-regulation of SAMHD1 gene construction of a prognosis biomarker for survival and prognostic in breast invasive carcinoma

Abstract

Abstract Background: SAMHD1 is an important intracellular dNTP triphosphate hydrolase and may play a role in the regulation of innate immune responses. Studies have found that SAMHD1 is mutated in many tumors and has functional significance. However, however, the impact of the SAMHD1 gene on breast invasive carcinoma is unclear. Methods:The RNA expression, variance analysis, copy number alteration and the clinical features, prognostic value of SAMHD1 gene in BRCA patients was evaluated using TCGA data. Pathway enrichment analysis of SAMHD1 gene was conducted using the R package cluster Profiler. In addition, we deeply explored the interaction between SAMHD1 gene and immunosuppressive tumor microenvironment (iTME) at the BRCA patients. Results: SAMHD1 gene expression was substantially lower in BRCA patients than normal. High SAMHD1 gene expression predicted worse long-term survival in BRCA patients. We also proved that SAMHD1 gene expression was positively correlated with the immune checkpoint genes, DNA damage repair (DDR) genes, and CD8+ T cell effector genes. Conclusions: Our results revealed that overexpression SAMHD1 gene lead to poor survival and construction of prognostic marker in BRCA patients.