Pathogen distrbution and drug resistance in acute, delayed and chronic periprosthetic joint infection: a retrospective analysis of 202 patients

Abstract

Abstract Introduction To assist orthopedic surgeons to select appropriate antibiotics, this study identified the common microorganisms that caused PJI and their drug-resistant spectrum. Methods. The clinical data of 202 patients with PJI after primary knee and hip arthroplasty from January 2017 to December 2021 were retrospectively analyzed. According to the time of postoperative infection, the patients were divided into acute PJI group (25 cases), delayed PJI group (91 cases), and chronic PJI group (86 cases). The results of pathogen species, composition ratio, drug susceptibility tests were collected. Results.The main pathogens of PJI were Gram-positive bacteria (58.91%, 119/202), and the positive rates of culture in patients with acute PJI, delayed PJI and chronic PJI were 32.00% (8/25), 62.64% (57/91) and 62.79% (54/86), followed by gram-negative bacteria (29/202, 14.36%) and fungus (4/202, 1.98%). Staphylococcus epidermidis and Staphylococcus aureus played an important role as well, followed by gram-negative bacteria (29/202, 14.36%) and fungus (4/202, 1.98%). Penicillin (81.25%), oxacillin (63.33%), erythromycin (61.17%) and clindamycin (48.35%) showed high antibiotic resistance rate in gram-positive bacteria. The drug-sensitivity to linezolid, vancomycin, daptomycin and tigecycline was 100%. The drug resistance rate to carbapenems was low, ranging from 0 to 3.57%. Conclusions. The main pathogens of PJI are Gram-positive bacteria, and the drug resistance rate of chronic PJI is higher than that of delayed and acute PJI.