Affiliation:
1. Institute of Biochemistry, National Academy of Sciences Armenia
2. Yerevan State Medical University Named after Mkhitar Heratsi
Abstract
Abstract
Spherical nanoparticles of silver were sensitized by glucose, lactose, dextran, and chitosan. Interactions of these nanoparticles with normal and cancerous tissues of the stomach and the intestine were studied. It was shown that nanoparticles sensitized with lactose interact selectively with cancer cells of the intestine, whereas glucose or dextran-sensitized nanoparticles interact selectively with stomach cancer cells. However, it should be noted that all of these nanoparticles interact to some extent with normal cells, also. Such nanoparticles loaded with anti-cancer drugs may be applied for selective action to these cancer cells
Publisher
Research Square Platform LLC
Reference25 articles.
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA: A Cancer J for Clinicials 2018; 68(6):394–424https://doi.org/10.3322/caac.21492
2. The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells;Daniels TR;Clin Immunol,2006
3. Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy;Bahrami B;Tumor Biol,2015
4. Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture;Imai Y;Cancer Res,1982
5. Doxorubicin: The good, the bad and the ugly effect;Carvalho C;Curr Med Chem,2009