Impact of hormone replacement therapy on all-cause and cancer-specific mortality in colorectal cancer: A systematic review and dose‒response meta-analysis of observational studies

Author:

Liu Kefeng1,He Yazhou2,Zhang Xianzhuo3,Yang Yongjie1,Sun Shusen4,Mei Zubing5,Zhao Jie1

Affiliation:

1. The First Affiliated Hospital of Zhengzhou University

2. Sichuan University

3. Lanzhou University

4. Western New England University

5. Shanghai University of Traditional Chinese Medicine, Anorectal Disease Institute of Shuguang Hospital

Abstract

AbstractBackground The effect of hormone replacement therapy (HRT) on colorectal cancer (CRC) mortality and all-cause mortality remains unclear. We conducted a systematic review and dose‒response meta-analysis to determine the effects of HRT on CRC mortality and all-cause mortality. Methods We searched the PubMed, Embase, and Cochrane Library electronic databases for all relevant studies published until June 2022 to investigate the effects of HRT exposure on survival rates for patients with CRC. Two reviewers independently extracted individual study data and evaluated THE risk of bias among the studies using the Newcastle‒Ottawa Scale. To examine a potential nonlinear relationship between the year of HRT use and CRC mortality, we performed a two-stage random effects dose‒response meta-analysis. RESULTS Ten cohort studies encompassing 480,628 individuals were included. The meta-analysis revealed that HRT was inversely associated with the risk of CRC mortality [hazard ratios (HR) = 0.77, 95% CI (0.68, 0.87), I2 = 69.5%, P < 0.05]. Pooled results from seven cohort studies revealed a significant association between HRT and the risk of all-cause mortality [HR = 0.71, 95% CI (0.54, 0.92), I2 = 89.6%, p < 0.05]. A linear (P for nonlinearity = 0.34) dose‒response analysis showed a 3% decrease in the risk of CRC for each additional year of HRT use; this decrease was significant [HR = 0.97, 95% CI(0.94, 0.99), P < 0.05]. An additional linear (P for nonlinearity = 0.88) dose‒response analysis showed a nonsignificantly decrease in the risk of all-cause mortality for each additional year of HRT use. CONCLUSIONS This study suggests that the use of HRT is inversely associated with all-cause and colorectal cancer mortality, thus causing a significant decrease in mortality rates over time. Further studies are warranted to confirm this association.

Publisher

Research Square Platform LLC

Reference51 articles.

1. Colorectal cancer;Kuipers EJ;Nat Rev Dis Primers

2. Nonlinear reduction in risk for colorectal cancer by oral contraceptive use: a meta-analysis of epidemiological studies;Luan NN;Cancer Causes Control

3. Colorectal cancer statistics, 2017;Siegel RL;CA Cancer J Clin

4. Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D, ESMO Guidelines Committee. ;. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017 Jul 1;28(suppl_4):iv22-iv40.

5. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.Lancet. 2015 Jan 10;385(9963):117–71.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3