Abstract
Abstract
In this study, periodic mesoporous organosilica (PMO)/ZnO nanocomposites were synthesized and investigated as a delivery system for the anticancer drug (gemcitabine). The green synthesis of ZnO nanoparticles used rice bran extract. The characteristic results show that as ZnO concentration was increased, spherical particle size increased while surface area and pore volume decreased. Between two nanocomposites, the maximum gemcitabine loading content (53.1%) is related to the sample with the lowest concentration of ZnO nanoparticles. For all samples, the gemcitabine release at pH=5.6 is greater than pH=7.4. In the first eight hours, the rate of gemcitabine release was rapid; however, it gradually slowed down. The release kinetics were fitted with the Higuchi model. The MTT assay showed the cytotoxicity effect of the nanocomposites on human colon cancer cell lines (HT-29).
Publisher
Research Square Platform LLC
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