Affiliation:
1. University of Tübingen
Abstract
Abstract
Background
SGLT2 inhibitors are used to reduce the risk of progression of chronic kidney disease (CKD). In patients with type 2 diabetes, they have been found to reduce extracellular volume. Given the high prevalence of extracellular volume expansion and overhydration in CKD, we investigated whether SGLT2 inhibitors might correct these disturbances in CKD patients.
Methods
CKD patients who started treatment with an SGLT2 inhibitor were investigated in this prospective observational study for 6 months. Body composition and fluid status were measured by bioimpedance spectroscopy. In addition, spot urine samples were analyzed for albuminuria, glucosuria and urinary aprotinin-sensitive serine protease activity.
Results
42 patients (29% with diabetic/hypertensive CKD, 31% with IgA nephropathy; 88% dapagliflozin 10 mg, 10% dapagliflozin 5 mg, 2% empagliflozin 20 mg; median eGFR 46 mL/min/1.73m² and albuminuria 1911 mg/g creatinine) participated in the study. Median glucosuria increased to 14 (10–19) g/g creatinine. At baseline, patients displayed overhydration (OH) with + 0.4 (-0.2–2.2) L/1.73m² which decreased by 0.5 (0.1–1.2) L/1.73m² after 6 months. Decrease of OH correlated with higher OH at BL, decrease of albuminuria, glucosuria and urinary aprotinin-sensitive protease activity. Adipose tissue mass was not significantly reduced after 6 months.
Conclusions
SGLT2 inhibitors reduce overhydration in patients with CKD, which is pronounced in the presence of high albuminuria, glucosuria and urinary aprotinin-sensitive protease activity.
Trial Registration
The study was registered at the German Clinical Trials Register (DRKS00028560).
Publisher
Research Square Platform LLC
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献