Losartan and Metamorphopsia

Author:

Mehrotra-Varma Jai1,Thinda Sumeer1

Affiliation:

1. Eye Medical Center of Fresno

Abstract

Abstract Background: Losartan, a commonly used hypertension medication, is associated with rare neurological side effects. This report presents the first case of losartan-linked bilateral metamorphopsia - a distortion of visual perception. Case Presentation: A 65-year-old woman with hypertension and myopic degeneration developed bilateral metamorphopsia while taking losartan. Despite normal retinal exams and neuroimaging, the symptoms persisted. Discontinuation of losartan led to symptom resolution over one year with no recurrence. Conclusions: This unique case emphasizes the need to evaluate drug-related adverse events in clinical diagnoses. Losartan's potential impact on the midbrain's visual processing regions may explain the observed visual disturbances. Further research is needed to explore this connection.

Publisher

Research Square Platform LLC

Reference5 articles.

1. Merck, Co INC. Losartan full prescribing information [FDA web site]. 2018. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020386s062lbl.pdf. Accessed August 14, 2022.

2. Nederlands Bikwerkingen Centrum Lareb. Losartan and psychiatric adverse drug reaction [Netherlands Pharmacovigilance Centre web site]. November 2005. Available at: https://databankws.lareb.nl/Downloads/kwb_2005_4_losar.pdf. Accessed August 14, 2022.

3. Walsh FB, Hoyt WF. Clinical Neuro-ophthalmology. Volume 1. Philadelphia: Lippincot Williams & Wilkins; 1969.

4. Reversal of vision metamorphopsia;River Y;Arch Neurol,1998

5. The role of angiotensin II in cognition and behavior;Gard PR;Eur J Pharmacol,2002

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