Affiliation:
1. AIIMS Rishikesh
2. National Institute of Pharmaceutical Education and Research (NIPER) S. A. S. Nagar
3. Amity University
Abstract
Abstract
The current landscape of antibiotic failures promotes researchers to turn their attention to nanotechnology. Therefore, in this study silver nanoparticles (AgNPs) were synthesized by using the leaf extract of Syzygium cumini. The spectrum of biosynthesized silver nanoparticles was noticed at 432 nm displaying a bell-shaped curve under UV-Vis spectroscopy. Transmission electron microscopy (TEM) showed that these nanoparticles have a spherical shape and diameter of 50–60 nm. FT-IR study has revealed the presence of phenolics, aromatic, and alkynes groups in the synthesized nanoparticles. These biosynthesized AgNPs were processed for antibacterial,anti-motility, and anti-biofilm activity. Results showed that AgNPs exhibit good antibacterial activity. A significant reduction in motility patterns has been visualized by the effect of AgNPs against P. aeruginosa and A. baumannii. Substantial and structural reduction in P. aeruginosa and A. baumannii biofilm morphology was also examined by the effect of AgNPs. Hence greener route of AgNPs synthesis may be validated as a feasible substitute in eliminating the infection caused by multi-drug resistant nosocomial pathogens.
Publisher
Research Square Platform LLC
Reference52 articles.
1. Alavi, M., & Karimi, N. (2018). Antiplanktonic, antibiofilm, antiswarming motility and antiquorum sensing activities of green synthesized Ag–TiO2, TiO2–Ag, Ag–Cu and Cu–Ag nanocomposites against multi-drug-resistant bacteria. Https://Doi.Org/10.1080/21691401.2018.1496923, 46(sup3), S399–S413. https://doi.org/10.1080/21691401.2018.1496923
2. pH effect on the aggregation of silver nanoparticles synthesized by chemical reduction;Alqadi MK;Materials Science-Poland 2014,2014
3. Role of Synthetic Plant Extracts on the Production of Silver-Derived Nanoparticles;Alzharani S;Plants,2021
4. Biological synthesis of silver nanoparticles using β-1, 3 glucan binding protein and their antibacterial, antibiofilm and cytotoxic potential;Anjugam;Microbial Pathogenesis,2018
5. Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses;Ayyanar M;Asian Pacific Journal of Tropical Biomedicine,2012