The Role of the Serum Uric Acid to Serum Creatinine Ratio in the 1-year Prognosis of Acute Isolated Pontine Infarction

Abstract

Abstract Background and Purpose Recent studies have shown that the serum uric acid to serum creatinine ratio (SUA/SCr) is associated with poor prognosis in acute ischemic stroke (AIS). The role of SUA/SCr as a new biomarker in acute isolated pontine infarction (AIPI) is unclear. The aim of this study was to investigate the relationship between SUA/CR and the 1-year clinical prognosis of AIPI. Methods Consecutive patients with AIPI were enrolled, and clinical and laboratory data were collected from these patients. Patients were followed up for 12 months after the onset of the disease, and their 1-year clinical prognosis was assessed using the modified Rankin Scale (mRS) score. Poor prognosis was defined as mRS score > 2, and the patients were classified into two groups accordingly. The characteristics of the clinical data, including demographics, laboratory data, and imaging indices, were compared between the 2 groups, and univariate and multivariate logistic regression were used to assess the predictive factors of the 1-year clinical outcomes of AIPI. Results Of the included 322 patients with AIPI, the mean SUA/SCr was 5.07±1.49. A total of 263 (81.7%) patients were included in the good prognosis group,and 59 (18.3%) were included in the poor prognosis group. SUA/SCr was higher in the poor prognosis group than inthe good prognosis group (p=0.002). After correction for confounders, multivariate logistic regression analysis showed that SUA/SCr [odds ratio (OR) 0.619; 95% confidence interval (CI) 0.462-0.831] at admission, National Institutes of Health Stroke Scale (NIHSS) score (OR, 1.735; 95% CI, 1.464-2.055), fasting glucose (OR, 1.190; 95% CI, 1.037-1.366), and age (OR, 1.037; 95% CI, 1.011-1.064) were independently associated with a poor prognosis at 1 year of AIPI. Spearman correlation analysis showed a negative correlation between SUA/SCr and mRS score (r=-0.152, P=0.006). Conclusions Reduced SUA/SCr values may be an independent predictor of poor prognosis in AIPI at 1 year. Reduced SUA/SCr in patients with AIPI is independently associated with long-term poor prognosis.