Diagnosis and Treatment Value of Percutaneous Transthoracic Needle Lung Biopsy in Pulmonary Hamartoma：A Retrospective Study

Abstract

Abstract Purpose The preoperative diagnosis of pulmonary hamartoma (PH) is a challenge, especially in patients with atypical imaging features. This study was aimed at exploring the application value of percutaneous transthoracic needle biopsy (PTNB) in the diagnosis and treatment of PH. Data and Methods: Patients who were diagnosed with PH and had undergone PTNB from our hospital were retrospectively reviewed. Other cases were retrieved from the literature prior to December 2022 regarding the use of PTNB in patients with PH. Patients’ age, sex, imaging characteristics of chest CT, the diagnosis by PTNB, cytology features of biopsy specimen, complications and further treatment were analyzed. Results In this retrospective study, a total of 47 patients who were diagnosed as PH and had undergone PTNB were analyzed. 6 of the cases were patients from our hospital from 2008 to 2022. Others were collected from the literature. The mean diameter of PH lesions was 24.1mm (8-60mm). The diagnosis accuracy of PTNB was 70.2%. The complication rate was 19.1%, mainly pneumothorax. Fibro myxoid stroma and chondroid material accounted for 48.9% and 38.3%, respectively. 16 cases underwent surgery, and follow-up was available for all the 47 patients and no significant growth of the PH lesion or recurrent was occurred. Conclusion PTNB might be a useful tool to diagnose PH with a lower incidence of complications. The lesion could be managed conservatively and surgical procedures can be avoided.