Poly acetyl amine grafted xanthan gum: Synthesis, Characterization and evaluation as Mucoadhesive Polymer

Abstract

Abstract Polyacetal amine grafted xanthan gum was synthesized by treating xanthan gum with chloroacetyl chloride which resulted in an intermediate to which ammonia was reacted. Proton NMR and IR spectrum confirmed the formation of poly-acetyl amine grafting on xanthan gum (MXG). The crystallinity of MXG was confirmed by DSC and XRD. SEM image indicates that the smooth polyhedral structure of xanthan gum changed to a rough spongy surface in MXG along with size and shape. Comparative mucoadhesion evaluation of MXG using goat buccal mucosa revealed higher ex vivo bio adhesion time as compared to xanthan gum. This improved mucoadhesion property of MXG can be attributed to the formation of attractive force between negative charge mucus and positive charged amine functionality. However, grafted polyhedral amine into xanthan gum backbone also enhanced other physiochemical properties such as viscosity, gelling property and swelling index etc. Acute oral toxicity and dermal toxicity studies reveals the safety of MXG. Therefore, this grafted polymer might be well exploited as a potential polymer for various drug delivery systems.