Early carotid pulse waves are associated with an acceleration of 18 F-FDG PET hypometabolism in Alzheimer’s brain areas

Author:

Zimmermann Gaétan1,Joly Laure2,Schoepfer Pauline2,Doyen Matthieu3,Roch Veronique1,Grignon Rachel1,Salvi Paolo4,Marie Pierre-Yves1,Benetos Athanase2,Verger Antoine1

Affiliation:

1. Université de Lorraine, CHRU Nancy

2. Université de Lorraine, CHRU-Nancy

3. Université de Lorraine, IADI, INSERM U1254

4. Instituto Auxologico Italiano, IRCCS

Abstract

Abstract Background Arterial stiffening likely plays a role in Alzheimer disease (AD) pathogenesis and may also favour a potentially deleterious early return of reflected arterial pressure waves. The current study investigated whether inter-individual variations in arterial stiffness and pressure wave parameters were associated with 18F-FDG positron emission tomography (PET) metabolism in AD-associated brain areas independently of age and before the onset of any neuropsychological disorders.Methods A prospective, large age-range population of 67 patients (17 young, 16 middle-aged, and 34 older adults; 37 women) with normal neuropsychological tests, underwent a: 1) brain 18F-FDG PET, 2) blood pressure recording and 3) carotid/femoral pulse wave-based measurements, including the time-to-peak of the reflected backward carotid pulse wave (bT), on the same day. Multivariate and quantitative voxel-to-voxel analyses (p-voxel < 0.005, corrected for cluster volumes) were conducted to assess associations between vascular parameters and 18F-FDG PET metabolism in AD-associated brain areas.Results In the multivariate analysis, only increased age and decreased bT were independently associated with the decline of metabolic activity in AD-associated brain areas (p < 0.001). In the voxel-to-voxel analysis with age as a covariate, bT was strongly associated with the metabolic activity of 40 clusters in AD-associated brain areas (clusters cumulative volume: 63 cm3; T score max: 5.7).Conclusion In patients, who are still unaffected by neuropsychological disorders, an early reflected arterial pressure wave, as evidenced by a decreased bT value, is strongly associated with an acceleration of the age-related decline in the metabolic activity of AD-associated brain areas.Trial registration : This research study was approved by the local ethics committee (CPP accreditation N°2018/26; date of registration : May,11th 2018).

Publisher

Research Square Platform LLC

Reference37 articles.

1. The link between cardiovascular risk, Alzheimer’s disease, and mild cognitive impairment: support from recent functional neuroimaging studies;Ferreira LK;Braz J Psychiatry. 10 juin,2014

2. Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study;Cortes-Canteli M;J Am Coll Cardiol. 23 févr,2021

3. Vascular contributions to cognitive impairment, clinical Alzheimer’s disease, and dementia in older persons. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;Kapasi A;1 mai,2016

4. Midlife and late-life obesity and the risk of dementia: cardiovascular health study;Fitzpatrick AL;Arch Neurol. mars,2009

5. High blood pressure, hypertension, and high pulse pressure are associated with poorer cognitive function in persons aged 60 and older: the Third National Health and Nutrition Examination Survey;Obisesan TO;J Am Geriatr Soc. mars,2008

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3