Affiliation:
1. Ardabil University of Medical Sciences
Abstract
Abstract
Background
Helicobacter pylori (H.pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix metalloproteinase-2 (MMP-2) to tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with a peptic ulcer that are sensitive or resistant to H. pylori treatment and compare them with healthy individuals.
Methods
In this study, 95 patients were included and divided into two groups sensitive (41 patients) and resistant to treatment (54 patients). The results were compared with a control group of twenty participants with normal endoscopy. After obtaining written informed consent, five ml of venous blood was taken to determine their serum MMP-2 and TIMP-1 levels using an enzyme-linked immunosorbent assay.
Results
In patients with H. pylori-induced peptic ulcers, the MMP-2/TIMP-1 ratio was significantly higher than those of the healthy controls (P < 0.05). MMP-2 level was associated with patients’ response to treatment (P < 0.05). The MMP-2/TIMP-1 ratio and the chance for refractory H. pylori-induced peptic ulcer disease were higher in patients with simultaneous gastric and duodenal ulcers (P < 0.05).
Conclusion
It seems that peptic ulcer disease caused by infection with H. pylori increases the MMP-2/TIMP-1 ratio in patients with peptic ulcers. However, it might not be a good predictor of refractory H. pylori-induced peptic ulcer disease.
Publisher
Research Square Platform LLC