Low-dose interleukin-2 for psoriasis therapy based on the regulation of Th17/Treg cell balance in peripheral blood

Author:

Qiao Zusha1,Zhao Wenpeng1,Liu Yan2,Feng Wenli1,Ma Yan1,Jin Hongzhong3

Affiliation:

1. Second Hospital of Shanxi Medical University

2. Shanxi Tumor Hospital

3. Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

AbstractThe imbalance between regulatory T (Treg) cells and efficient T cells plays an important role in psoriasis. Low-dose interleukin (IL)-2 can preferentially activate Treg cells and ameliorate the imbalance of Treg/efficient T cells. This study focused on the status of circulating CD4 + T subsets and the clinical efficacy of low-dose IL-2 therapies in psoriasis. This retrospective study included peripheral blood samples obtained from 45 psoriasis patients and 40 healthy controls. The 45 psoriasis patients received three cycles of subcutaneous low-dose IL-2 treatment (0.5 million IU/day for 2 weeks) combined with conventional therapies. Inflammatory indices, CD4+T lymphocyte subsets, and cytokines were measured in all patients before and after treatment. The percentage of Treg cells was dramatically decreased in the psoriasis group compared to the healthy group, and the percentage of Treg cells negatively correlated with the disease indices and the psoriasis area and severity index (PASI) (P < 0.001). The Th17/Treg ratio was significantly increased in the psoriasis group compared to the healthy group, and the Th17/Treg ratio positively correlated with disease indices and PASI (P < 0.001). Low-dose IL-2 treatment significantly amplified the percentage of Treg cells and restored the Th17 and Treg immune balance in psoriasis (P < 0.001). Low-dose IL-2 combination therapy effectively improved the clinical manifestations of psoriasis but decreased the inflammatory indicators of the disease activity, with no apparent side effects. Thus, low-dose IL-2 provides a new strategy for the treatment of psoriasis.

Publisher

Research Square Platform LLC

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