The efficacy of Levonorgestrelintrauterine system, Drospirenone & Ethinylestradiol Tablets(II) and Dydrogesterone in preventing the recurrence of endometrial polyps

Abstract

Abstract Objective: To analyze the efficacy of Levonorgestrelintrauterine system, Drospirenone & Ethinylestradiol Tablets(Ⅱ), and Dydrogesterone in preventing the recurrence of endometrial polyps after hysteroscopic endometrial polypectomy. Methods: 170 patients who underwent hysteroscopic endometrial polypectomy in the Gynecology Department of Tianmen First People's Hospital in Hubei Province from January 2022 to June 2023 were randomly divided into the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, Dydrogesterone group, and a control group. The recurrence rates, endometrial thickness, and menstrual volume changes at 6 and 12 months post-operation were compared among these four groups. Results: The recurrence rates in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group were lower than the control group, with statistical significance (P < 0.01), with the Levonorgestrelintrauterine system group having the lowest recurrence rate. The endometrial thickness at 6 and 12 months post-operation in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group was thinner than that of the control group and thinner than pre-operation, with statistical significance (P < 0.01). The menstrual volume at 3 months post-operation in the Levonorgestrelintrauterine system group, Drospirenone & Ethinylestradiol Tablets(Ⅱ) group, and Dydrogesterone group was significantly less than the control group, and less than the pre-operation volume. Conclusion: Dydrogesterone, Drospirenone & Ethinylestradiol Tablets(Ⅱ), and Levonorgestrelintrauterine system all play a role in preventing the recurrence of endometrial polyps, but Levonorgestrelintrauterine system is significantly better than Dydrogesterone and Drospirenone & Ethinylestradiol Tablets(Ⅱ) in terms of post-operative recurrence rate, endometrial thickness, menstrual changes, and compliance, and is worth promoting in clinical application.