Effect of different fractions of inspired oxygen on ventilator-induced lung injury during prolonged mechanical ventilation in surgery-Reference-Cited by-同舟云学术

Effect of different fractions of inspired oxygen on ventilator-induced lung injury during prolonged mechanical ventilation in surgery

Published:2022-10-05 Issue: Volume: Page:
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Author:

Fan Jian-ping¹,Qian Ying-cong²,Chang Xiao-lan³,Men Xiao-wen³,Ji Fu-hai³,Liu Silan³,Lu Xiang-hong³

Affiliation:

1. The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University

2. Dushuhu Public Hospital Affiliated to Soochow University

3. The first Affiliated Hospital of Suzhou University

Abstract

Abstract Purpose Explore the effect of different intraoperative fraction of inspiration O2(FiO2) on perioperative lung injury through this trial. Methods 102 patients undergoing lower abdominal surgery under general anesthesia were randomly divided into three groups: group A（FiO230%）,B(FiO250%) and C(FiO280%). The concentrations of surfactant protein A (SP-A) and Clara cell protein 16(CC16) in plasma, which reflect lung injuries, were also detected by ELISA at T0(10 minutes before anesthesia), T1(1 hour after intubation)and T2(3 hours after intubation). Lung ultrasound (LUS) was used to calculate LUS scores of all patients at T0 and T3(30 minutes after extubation) to evaluate the incidence and severity of atelectasis after surgery. Results 90 patients were enrolled in this trial. Compared with T0, SpO2 decreased significantly at T3 in all three groups(P<0.05). PaO2/FiO2 was higher in group A than in groups B and C at T2 and T3(P<0.05). PaO2/FiO2 decreased with the ventilation duration in all three groups(P<0.05). Compared with T0, the incidence of atelectasis and LUS scores increased significantly at T3 in the three groups (P<0.05). Conclusion Intraoperative 30% FiO2 ca nalleviate lung injury, improve oxygenation and reduce either incidence or severity of atelectasis in patients receiving prolonged mechanical ventilation(3~5h) during surgery with general anesthesia. Trial registration: Clinicaltrials.gov ChiCTR2000029075.

Publisher

Research Square Platform LLC

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