Optimizing Jojoba Oil Methanolysis and Unveiling the Immunomodulatory Potential of cis-13-Docosenol Fatty Alcohol: A Circular Biorefinery Perspective

Author:

Mendoza Laura1,Sánchez Marcos2,Marchetti Jorge Mario3,Montoya María1

Affiliation:

1. Margarita Salas Center for Biological Research (CIB), CSIC

2. Fundación Centro Tecnológico de Investigación Multisectorial (CETIM), A Coruña

3. Norwegian University of Life Science

Abstract

Abstract

To ensure the sustainability of Jojoba oil production, research and development must prioritize the adoption of environmentally friendly extraction processes. Firstly, optimal conditions for extracting Jojoba oil were predicted marking a significant step towards realizing its economic potential. Molar ratio, temperature and catalysts concentration were taken into consideration to achieve optimal production. Secondly, interactions of cis-13-docosenol (C13D), a key component of Jojoba oil, with innate immune cells were analysed. By meticulously examining the interactions between C13D and critical elements of the innate immune system, including monocytes, macrophages, and dendritic cells (DC), we aim to uncover the immunomodulatory properties of this compound. In experiments with THP-1 cells and DC, low doses of C13D were found to elevate pro-inflammatory cytokines TNF-α, IL-6, and IL-1β to levels comparable to those induced by LPS. Furthermore, modulation of T cell stimulation by monocyte-derived dendritic cells (MoDC) previously treated with C13D resulted in increased T cell proliferation, likely due to the enhanced activation of surface markers. This detailed exploration into the effects of C13D on innate immune cells not only deepens our understanding of Jojoba oil's therapeutic potential but also establishes a foundation for future advancements in immunology and biotechnology.

Publisher

Springer Science and Business Media LLC

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