In vivo Brain Estrogen Receptor Expression By Neuroendocrine Aging And Relationships With Gray Matter Volume, Bio-Energetics,
and Clinical Symptomatology
Author:
Mosconi Lisa1, Jett Steven1, Nerattini Matilde1, Andy Caroline1, Yepez Camila Boneu1, Zarate Camila1, Carlton Caroline1, Kodancha Vibha1, Schelbaum Eva1, Williams Schantel1, Pahlajani Silky1, Loeb-Zeitlin Susan1, Havryliuk Yelena1, Andrews Randolph2, Pupi Alberto3, Ballon Douglas4, Kelly James1, Osborne Joseph1, Nehmeh Sadek1, Fink Matthew1, Berti Valentina3, Matthews Dawn2, Dyke Jonathan1, Brinton Roberta Diaz5
Affiliation:
1. Weill Cornell Medicine 2. ADM Diagnostics 3. University of Florence 4. Weill Medical College of Cornell University 5. University of Arizona
Abstract
Abstract
17β-estradiol,the most biologically active estrogen, exerts wide-ranging effects in brain through its action on estrogen receptors (ERs), influencing higher-order cognitive function and neurobiological aging. However, our knowledge of ER expression and regulation by neuroendocrine aging in the living human brain is limited. This in vivo multi-modality neuroimaging study of healthy midlife women reveals progressively higher ER density over the menopause transition in estrogen-regulated networks. Effects were independent of age and plasma estradiol levels, and were highly consistent, correctly classifying all women as being post-menopausal or not. Higher ER density was generally associated with lower gray matter volume and blood flow, and with higher mitochondria ATP production, possibly reflecting compensatory mechanisms. Additionally, ER density predicted changes in thermoregulation, mood, cognition, and libido. Our data provide evidence that ER density impacts brainstructure, perfusion and energy production during female endocrine aging, with clinical implications for women’s health.
Publisher
Research Square Platform LLC
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