Affiliation:
1. Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital
2. Jiangxi Cancer Hospital of Nanchang University
Abstract
Abstract
Objectives
This study aims to explore the feasibility of sparing concurrent chemotherapy (CCT) after induction chemotherapy (ICT) in low-risk locoregionally advanced nasopharyngeal carcinoma (LANPC).
Materials and methods
LANPC patients(excluding N3/T4N2) who received ICT + CCRT/RT alone between January 2014 and December 2018 were candidates for this retrospective study. All the enrolled patients should achieved favorable response(CR/PR) after ICT.
Results
A total of 336 patients were included. No significant differences in 4-year OS, LRFFS, DMFS and PFS (all p > 0.05) between ICT + IMRT and ICT + CCRT groups were observed. Multivariate analysis confirmed that CCT was not an independent prognostic factor for all survival outcomes (p > 0.05). Patients in the ICT + IMRT group had a significant lower incidence of grade 3–4 mucositis than those in the ICT + CCRT group (29.4% vs. 40.4%, p = 0.037), and other toxicities did not differ significantly.
Conclusions
Sparing CCT in those who achieved favorable response after ICT is feasible and has lower incidence of acute adverse events. Well-designed prospective clinical trials are expected to confirm our results.
Publisher
Research Square Platform LLC
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