The usefulness of left and right ventricular GLS assessment and biomarker concentrations in cardiovascular risk stratification in patients qualified for hematopoietic stem cell transplantation due to hematopoietic and lymphoid malignancies – a pilot study description

Abstract

Abstract Due to the cytostatic agents used and the risks associated with peri-transplant procedures, the hematopoietic stem cell transplantation (HSCT) procedure is considered a cardiovascular burden. We designed a pilot study to determine the clinical utility of the new ST2 marker and routinely assessed cardiac parameters in HSCT recipients. Based on the previous cardio-oncology experience in lung and prostate cancer, we can confirm the prognostic and predictive value of classic cardiac biomarkers and modern echocardiography parameters such as global longitudinal strain of the left and right ventricle. After conducting this pilot study, we can create a predictive and prognostic model for patients undergoing HSCT. This will greatly enrich our clinical practice, especially in treating older people.