Abstract
Aim
The Oxidative Balance Score (OBS) functions as a measure for gauging the oxidative stress condition, OBS has been utilized to assess the overall oxidants and antioxidants exposure status in various chronic disease studies, Growing evidence suggests that oxidative stress is involved in the pathophysiologic mechanisms of endometriosis, The purpose of this study was to investigate the association between OBS and endometriosis in women between the ages of 20 and 54.
Methods and Results
The correlation between OBS and endometriosis was meticulously examined through a multifaceted approach, encompassing multivariate logistic regression, sensitivity analysis, and the application of smoothing techniques for curve fitting. This analysis was conducted utilizing the extensive dataset from the National Health and Nutrition Examination Survey (NHANES) spanning the years 1999 to 2006. To ascertain the stability of the observed relationship across diverse demographic segments, subgroup analysis, and interaction tests were meticulously implemented. Among the 3881 participants aged between 20 and 54 years, a significant inverse association was identified between OBS scores and the presence of endometriosis. Specifically, within the comprehensively adjusted model, for every 1 score increase in OBS, the odds of endometriosis prevalence decreased by 2.00%. The highest quartile of OBS demonstrated a 29.1% reduction in the prevalence of endometriosis when compared to those in the lowest quartile, with a confidence interval of [0.480, 1.048], underscoring the robustness of the observed trend.
Conclusions
OBS is related to endometriosis among American adults. Our results suggest that elevated OBS may potentially reduce the odds of endometriosis prevalence.