The Speed-Gene study: methods, study design and preliminary results

Abstract

Abstract The Speed-Gene study aims to identify genetic variants that influence athletic performance and human locomotion using motion capture technology. Currently 33 participants have already completed the study and the overall aim is to recruit 100 moderately-trained, healthy South-East Asians (all males 18–45 y, BMI < 30). Participants will undergo biomechanical analysis and genetic testing. A number of analyses will be performed, including (but not limited to) linear and angular kinematic analysis using motion capture technology, force plate dynamometry as well as various anthropometric assessments. Pretesting beverages will be provided and activity history as well as current activity levels will be assessed by a questionnaire. The kinematic and force data will be obtained using a Qualisys Track Manager (QTM) system, and DNA will be isolated from white blood cells using standard procedures. The participants will serve as their own controls. Even though the gene Speed-Gene study is tightly controlled, our preliminary findings still indicate considerable individual variability. More participants and further genetic analysis are required to allow us to investigate potential underlying genetic mechanisms responsible for this individual variability.