Dysregulation of long non-coding RNA Rian expression in the brain of memory-impaired diabetic mice

Abstract

Abstract Type 1 diabetes mellitus (DM) is a metabolic disease caused by complications in the body. One of these complications is memory deficit and learning disability. The hippocampus (HP) and prefrontal cortex (PFC) are the main regions of the brain involved in memory and learning. HP and PFC regions have specific long noncoding RNA (lncRNA) signature that possibly regulate their functions. In this study, we aimed to evaluate highly-expressed lncRNAs level change in the brain of diabetic mice. The diabetic mice were divided into memory loss and normal memory groups. The lncRNA expression changes were measured in HP and PFC regions. The expression level of several lncRNAs was changed in HP and PFC. Most importantly lncRNA Rian was increased in PFC and HP regions post-diabetes. The lncRNA Rian protects neuronal cells from injuries through GATA3 regulation. It is possible that overexpression of Rian is a protective response to diabetes-related injuries. In conclusion, our data demonstrated that several lncRNAs expressions have changed in the HP and PFC of diabetic mice suggesting the potential therapeutic targets for the alleviation of diabetes-induced neuronal toxicity.